TRANSLATIONAL PHYSIOLOGY Hormonal regulation of hepatic multidrug resistance-associated protein 2 (Abcc2) primarily involves the pattern of growth hormone secretion
نویسندگان
چکیده
Francis R. Simon, Mieko Iwahashi, Ling-Jia Hu, Ishtiaq Qadri, Irwin M. Arias, Daniel Ortiz, Rolf Dahl, and Eileen Sutherland Department of Medicine, Division of Gastroenterolgy and Hepatology, University of Colorado Health Sciences Center, Denver, Colorado; Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts; and Unit of Cellular Polarity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
منابع مشابه
Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.
The disposition of fexofenadine, a commonly used antihistamine drug, is governed primarily by active transport. Biliary excretion of the parent compound is the major route of systemic clearance. Previous studies demonstrated that fexofenadine hepatic uptake is mediated by organic anion transporting polypeptides. Recently, we showed that in mice fexofenadine is excreted into bile primarily by mu...
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Multidrug resistance-associated protein 2 (MRP2)/ATP-binding cassette protein C2 (ABCC2) and multidrug resistance protein 1 (MDR1)/ABCB1 are well-known efflux transporters located on the brush border membrane of the small intestinal epithelia, where they limit the absorption of a broad range of substrates. The expression patterns of MRP2/ABCC2 and MDR1/ABCB1 along the small intestinal tract are...
متن کاملThe role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2).
Multidrug resistance-associated protein 2 (Mrp2, Abcc2), an organic anion transporter present in the apical membrane of hepatocytes, renal epithelial cells, and enterocytes, is postulated to undergo post-transcriptional regulation. We hypothesized that Mrp2 protein undergoes altered rates of protein synthesis or degradation consistent with different Mrp2 protein expression. We analyzed Mrp2 syn...
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